The Endless Summer
نویسندگان
چکیده
People with metabolic syndrome and obesity are at an increased risk of mortality from cardiovascular disease. Over the past decade, there has been intensive research into new ways to stimulate weight loss to lower this risk. One of the key tissues is the metabolically active brown adipose tissue (BAT). Given that this is a thermogenic tissue, it can be stimulated by cold and is suggested by some as a new frontier in weight loss and improvements in other aspects of human health. But what does this mean for the health of our arteries? In the current issue of Circulation Research, Williams et al, reveal that ambient cool temperature may not correlate to benefit in our blood vessels. By comparing atherosclerotic lesion development over a series of temperatures and in 2 atherosclerotic prone models, they reveal stark differences in plaque size, such that larger lesions are found in animals under cold conditions. Their studies reveal a novel temperature-sensitive modulation of monocyte release from the bone marrow that ultimately impacts atherogenesis. Importantly, Williams et al have also uncoupled the metabolic protective role of the heatgenerating UCP1 (uncoupling protein 1) from atherosclerosis.
منابع مشابه
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iii ACKNOWLEDGEMENTS I would like to express my wholehearted appreciation to my advisor, Dr. Zhuomin Zhang, for his endless support, encouragement, and guidance during my Ph.D. study. His invaluable advice and constructive suggestions have motivated me to further improve myself and excel in my research. I would also like to thank Dr. Benjamin Tsai (my supervisor during the summer internship pro...
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